These
are sterile preparation which is applied to the eye in the form of drops,
ointment, suspension or ocuserts.
Sterilization
the ophthalmic preparation by:
1. Dissolved active
constituent in suitable solvent which contain antimicrobial agent → filter→ trans
to final container & firm close → sterilized in autoclave (121
for 20min.)
2. The same later step with
sterilized & firm close without use autoclave.
3. The same later step
without use autoclave but storage at 98
→ 100
for 30min.
Why
Sterilization the ophthalmic preparation?
Because
pseudomonas aeruginosa → corneal ulceration → blindness.
The
preservative used in ophthalmic preparation:
1. Benzalkonium: has broad
spectrum but not effecting against pseudomonas aeruginosa so used with
polymycinB.
2. Phenyl mercuric nitrate:
it ppt on the eye lens if it is used for long time so don't used with glaucoma.
Packaging
of ophthalmic
solution & suspension: in an opaque
flexible plastic container made of nylon fitted with a fixed or building
dropper.
Packaging
of ophthalmic
ointment: into a collapsible tin or plastic
tube which closed with screw caps which made of aluminum or plastics.
Ocuserts: a newly device for the insertion of the drug to the lower eye lid which
provide a constant and continues drug release for long period of time.
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