Tablets manufacturing

Tablet definition: it is solid dosage form contain drug substances with or without suitable diluents & prepared by compression or molding methods.

Steps of tablets manufacturing:

1.  Weighting of initial components ( raw material)

2.  Mixing the component material together to get homogenous powder mixture.

3.  Granulation: powder particles adhere to form large particles (granules)

4.  Lubrication: addition of lubricants to decrease friction between powder particles & between powder particles and machine.

5.  Compression: conversion of powder of active ingredients to defined shape tablet by pressing it.

Machines used in tablet preparation:

1.  Mixers (powder mixers):

a.  V-mixer: V shaped stainless steel mixer

Advantage:

1.  Easy to clean & discharge.

2.  Need low power & low maintenance.

b.  Double cone mixer: di-cone shaped stainless steel mixer.

Advantage:

1.  Has high convection mixing (convection mixing is transferring of adjacent particles from one location to another.

2.  Tablet pressing (compression) machine: it is a machine basically involve many punches & dies in a circular arrangement.