Action
and use
Cyclo-oxygenase
inhibitor; analgesic; anti-inflammatory.
Content
of mefenamic acid, C15H15NO2
95.0 to
105.0% of the stated amount.
Assay
Weigh
and powder 20 tablets. Dissolve a quantity of the powdered tablets containing
0.5g of Mefenamic Acid in about 80ml of warm absolute ethanol previously neutralised to phenol red solution
alternating between heating and ultrasound to aid dissolution. Cool, add sufficient of the
neutralised absolute ethanol to produce 100ml, mix well and titrate with 0.1M
sodium hydroxide VS using phenol red solution as indicator.
Each ml of 0.1M sodium hydroxide VS is
equivalent to 24.13 mg of C15H15NO2.
Calculation:
Result:
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